Key summary Rejuran involves injections at multiple points, so you should factor in pain and needle marks. How it feels varies depending on the product, treatment area, and anesthesia method, and the time for the embossed bumps to flatten and bruising to fade also differs. Makeup and sauna use should follow product-specific guidelines, and you shouldn't take the 6~12 months that clinics explain as the same maintenance period for everyone. Once you decide which product to use and where to inject it, you can have a more specific consultation about pain management and scheduling.
01 What's the difference between Rejuran Healer, HB Plus, and Eye?
You need to distinguish between Healer, used across the whole face; HB Plus, which contains an anesthetic ingredient; and Eye, introduced for the eye area. Rejuran is a family of injectable products that use PN, or polynucleotide, an ingredient derived from salmon. It's discussed with the goal of improving skin texture and fine lines, which differs from the consultation goal for fillers that add volume to sunken areas. The ingredients and approved scope vary by product and need to be checked separately.
- Healer is the product clinics introduce when discussing overall facial skin texture and elasticity. LEIN Clinic describes it as a product used on the entire face.
- HB Plus contains PN, hyaluronic acid, and the local anesthetic lidocaine. Don't assume it's simply Healer with the same ingredient concentration plus added anesthetic. If you have a lidocaine allergy, you should inform the clinic before booking.
- Eye is introduced as a product for thin skin around the eyes. The fact that it's named for the eye area doesn't mean it's injected the same way everywhere around the eyes.
According to the manufacturer's HB Plus instructions, the approved purpose is the temporary improvement of fine lines at the outer corners of the eyes in adults, and the South Korean manufacturing permit number is 21-629. You should distinguish between the overall facial glow or skin texture improvement that clinics describe and the product's approved labeling language. If you're receiving treatment in a thin area such as around the eyes or lips, you should ask about the exact product name and precise injection site during your consultation.
For ingredient details and research background, see the Rejuran Evidence Guide. If you are considering filler, see the Nasolabial Fold Filler and Lifting Guide for the purpose of adding volume and the criteria for choosing treatment.
02 Does it hurt a lot? Is numbing cream alone enough to get through it?
Some people have reported pain even with numbing cream, while others have said they got through it comfortably with HB Plus or additional anesthesia. It's hard to pin pain down to a single number. Even with the same Rejuran, the product, treatment area, and injection method used can differ, so you shouldn't expect another person's experience to be exactly how much pain you'll feel.
Link Plastic Surgery Clinic explains numbing cream and cooling care as its standard approach, and offers a sleep sedation option to people who are sensitive to pain. Reberry Clinic Gangnam, part of a larger network, applies cream for 30 to 40 minutes before treatment and explains pain in the forehead and cheekbone areas separately. YOU&I Clinic Busan introduces HB Plus, which contains lidocaine. All of these are explained in each clinic's own way.
If you're considering a sleep procedure, ask not only about the pain from the injections themselves but also about the process of waking up from anesthesia. A review saying that using Airnox felt comfortable and a review saying someone felt nauseous after sleep sedation are the experiences of different people. You can't read these as proof that one method is always less painful or that recovery is always easier.
During the consultation, ask questions like "How long do you apply the numbing cream?", "Do you also use cooling?", and "What's the recovery and discharge guidance after additional anesthesia?" You can also ask whether the injection is done by machine or by hand, but don't expect that the name of the method alone means there will be no pain. There's also no basis in these reviews for concluding that choosing sleep anesthesia alone means bruising will last longer.
03 How long do injection bumps and bruising remain? When should I contact the clinic?
Swelling bumps are small raised bumps on the skin, and bruising is discolored skin after an injection. You need to think about the recovery time for each of these separately. Link Plastic Surgery Clinic describes swelling bumps as lasting 1 to 2 days, while the recovery section on the same page lists 1 to 3 days. YOU&I Clinic Busan explains that swelling bumps last around 2 to 3 days and can continue for 5 to 7 days depending on the area and skin type.
This duration refers to the clinic's guidance on how long the small injection bumps last. It doesn't mean that bruising disappears within that same period as well. The two reviews below describe different experiences, one where the small injection bumps went down within a day and another where the bruising lasted 3 weeks.
Beautystone Clinic advises contacting the clinic if swelling or itching continues for more than 3 days. The HB Plus manufacturer's instructions state that patients should seek prompt medical attention if inflammation lasts more than a week or unexpected side effects occur. If your clinic gave you an earlier contact threshold, follow that guidance.
If you experience severe symptoms such as changes in vision or difficulty breathing, seek immediate medical attention without waiting several days. The HB Plus instructions warn that intravascular injection can cause serious complications, including blindness. These warning signs should never be dismissed as part of a normal recovery process alongside an ordinary injection mark.
04 When can I start washing my face, wearing makeup, using a sauna, or exercising?
Follow the restrictions in the product instructions first, and follow the schedule set by the clinic that performed your procedure for washing your face and exercising. HB Plus instructs patients to avoid makeup for 12 hours after injection and to avoid prolonged exposure to sunlight, UV rays, cold, and heat for 2 weeks. Saunas and steam rooms are included under heat exposure.
Clinics' general guidance on Rejuran varies. Link Plastic Surgery Clinic explains that makeup can be worn starting the next day, while saunas and strenuous exercise should be avoided for 24 to 48 hours. S-Reborn Clinic Hongdae advises light face washing and makeup the next day, while avoiding saunas and strenuous exercise for 7 days. YOU&I Clinic Busan explains that patients can wash their face after 2 to 3 hours, wear makeup starting the next day, and should avoid exercise for about 1 week.
If you are receiving HB Plus, don't shorten the 2-week restriction based only on a clinic's general sauna guidance. After confirming which product was used in your procedure, you can ask, "Based on this product's instructions and my treatment area, when can I start this?" For next-day makeup as well, you should first check whether 12 hours have passed since the time of your procedure.
Before any procedure, you must disclose allergies, medications, and any previous filler history. HB Plus has contraindications including hypersensitivity to its ingredients, pregnancy and breastfeeding, minors, and infected areas, and restrictions also cover medications such as anticoagulants. The same area is also excluded if you have recently had filler or have a permanent filler already in place. Do not stop prescribed medications on your own; decide with your doctor whether the procedure can proceed.
05 How many sessions are needed? Does it last 6 months to 1 year?
Separate the initial session count the clinic describes from the interval for later maintenance sessions. Link Plastic Surgery Clinic describes 2–3 sessions at 3–4 week intervals, while elsewhere on the same page it describes 2–3 week intervals. After that, it presents maintenance sessions every 3–6 months. YOU&I Clinic Busan describes 3–4 sessions at 3–4 week intervals, lasting about 6 months. Reberry Clinic describes a duration of 6–12 months and maintenance sessions at intervals of 6 months to 1 year. Even within the same clinic, the initial interval differs page to page, so you need to hear the plan again during consultation.
A plan involving several consecutive sessions at the start is initial treatment to build up change, while receiving it again a few months later is maintenance treatment. If you interpret "3 sessions and you're done" literally, the later schedule and cost will differ from what you expected. During consultation, ask not only about the number of sessions but also what criteria — skin texture, fine lines, or dryness — are used to decide on additional sessions.
There is also research that followed patients for several months. A 2025 systematic review compiled 9 studies and 219 patients, and a study using Rejuran around the eyes in 27 women had a follow-up period of 28 weeks. Other studies covering different products or combined procedures followed patients for 6 months. Results need to be read according to which product was used and where it was injected in each case.
However, these sources cannot be combined to conclude that all Rejuran products last 6–12 months across the entire face. PN and PDRN, different products and injection sites, and whether other procedures were performed together are all mixed in. In studies with small sample sizes, a few patients' experiences can substantially shift the results, and the study methods also differ, so they cannot be combined into one average effect. You need to distinguish between the maintenance plan a clinic describes and the duration observed in a specific study.
06 When Do You Start Feeling the Effects? Does It Change in a Week?
Some reviews mention noticing changes in the skin after about a week, but that timeline can't be treated as the standard for everyone. The HB Plus review below, written on day 37 after the procedure, recalls starting to feel changes around the one-week mark. On the other hand, another reviewer wrote that the effects of a previous clinic's procedure were minimal. The two reviews reflect individual experiences with different products and procedure conditions.
Larger injection bumps or swelling immediately after injection do not mean a greater effect. YOU&I Clinic Busan also explains that the absence of small injection bumps doesn't mean there's no effect. During recovery, watch to see whether the raised areas settle down, and when discussing results, compare how the skin texture or fine lines you originally wanted to address have actually changed.
If the results fall short of expectations after one session, try explaining what change feels insufficient rather than immediately increasing the dose. If your original concern, such as sunken volume or significantly sagging skin, differs from skin texture, you'll need to realign the treatment goal first. It also helps to distinguish between the satisfaction expressed in reviews and the improvement items evaluated by a physician.
07 How Should You Choose Based on Your Situation?
When Pain Is Your Biggest Concern
Consult about HB Plus's ingredients along with numbing cream, cooling, and additional anesthesia. Mention any lidocaine allergy or past discomfort after anesthesia first, and also ask how the procedure is adjusted if pain is severe. What matters more than a single review saying it was comfortable is whether the method applied to you and the recovery guidance are specific.
When a Photo Shoot or Wedding Is Coming Up
Don't assume the day the small injection bumps settles and the day bruising disappears will be the same. Link Plastic Surgery Clinic advises brides-to-be to finish their last procedure 4 to 6 weeks before the wedding day. This isn't a guarantee that this interval is sufficient for everyone, but it's distinct from a plan to get a first-time procedure right before an important day. Share your actual date and makeup schedule, and set the timing for your last procedure accordingly.
When Your Only Concern Is a Thin Area Like Under the Eyes
Do not apply the product and dosage used for full-face treatment as-is; first decide whether you want to improve fine wrinkles or hollowing. Because the HB Plus package insert separately warns about the risk of vascular injection near the eye area, you should have the doctor explain the product's approved injection site and the actual injection location. Do not assume there is no pain or risk just because a product is named for the eye area.
Pre-consultation checklist
- □ Were you told the product name, treatment area, and dosage?
- □ Were you given guidance on cream application time, cooling, additional anesthesia, and recovery and going-home instructions?
- □ Did you disclose allergies, medications you are taking, pregnancy and breastfeeding status, and any previous filler history?
- □ Did you ask when you can start makeup, face washing, exercise, and sauna use respectively?
- □ Did you set the timing of your last treatment to fit an important schedule?
- □ Were you told the number of initial sessions, the maintenance treatment plan, and where to contact if you experience abnormal symptoms?
In summary
In your consultation, decide in order on the product name and area, ways to reduce pain, and the date you can return to daily life. Maintenance treatments can be decided based on the change you initially aimed for and your actual progress. Rather than picking out appealing phrases from reviews, it helps the consultation more to first state the level of pain and recovery period you personally can and cannot tolerate.
Frequently Asked Questions
If I just apply numbing cream for Rejuran, will it not hurt?
There is no guarantee that pain will disappear. Some people have found it difficult even with the cream alone. Consult about the product, area, and whether to add cooling or additional anesthesia, but do not decide how much pain you will feel based solely on other people's reviews.
Can I apply makeup right after getting Rejuran HB Plus?
The manufacturer's package insert specifies avoiding makeup for 12 hours. If you are planning to apply makeup the next day, check how many hours have passed since the time of treatment and also follow your clinic's guidance.
How many days should I avoid sauna and exercise after Rejuran?
HB Plus specifies avoiding prolonged heat exposure such as sauna for 2 weeks. Exercise guidance varies by clinic, so you should set your start date according to the product and area. Do not use general Rejuran guidance alone to loosen the restrictions for HB Plus.
How long do injection bumps and bruising last after Rejuran?
Link Plastic Surgery Clinic describes small injection bumps as lasting 1 to 3 days, and YOU&I Clinic Busan advises that it can remain until day 5 through 7. Bruising should be considered separately. If symptoms worsen or unexpected symptoms occur, contact the clinic rather than waiting until the scheduled recovery period ends.
How many sessions of Rejuran are needed?
For initial treatment, Link Plastic Surgery Clinic advises 2 to 3 sessions, and YOU&I Clinic Busan advises 3 to 4 sessions. Rather than applying a fixed number of sessions to everyone, the plan should be determined based on the concern to be improved and the recovery progress. Subsequent maintenance treatments are separate from the initial treatment.
Does Rejuran last from 6 months to 1 year?
This is a duration that some clinics advise, and it is not a guaranteed duration for all products and areas. The literature review includes follow-up studies of 28 weeks or 6 months, but because products, concurrent procedures, and evaluation criteria differ, these cannot be combined into a single duration.
Related guides to read together
Sources and verification date
Data as of: 2026-10-24.
- Rejuran HB Plus Manufacturer Instructions. Document dated 12 2024, DB 0233 (02). Manufacturing permit 21-629, ingredients and approved purpose, aftercare, and contraindications and warnings. This guidance applies to HB Plus.
- Pharma Research Rejuran Product Line Guide. Manufacturer press release dated 2024-04-09. Covers the product lineup and HB Plus lidocaine information, kept separate from independent research.
- PMID 39645667, Public full text. A 2025 systematic review covering 9 studies and 219 patients. Subjects, products, and evaluation methods differed, so no pooled analysis was performed. Some authors have advisory and educational ties to related companies.
- Link Plastic Surgery Clinic Rejuran Guide. The clinic's own description of anesthesia, small injection bumps technique, initial and maintenance treatments, and the interval before the main procedure.
- Reberry Clinic Rejuran Guide, Healer Guide. The intervals differ between the two pages, so they were not combined into a single schedule.
- YOU&I Clinic Busan HB Plus Guide, S-Reborn Clinic Hongdae Guide, Beautystone Clinic Skin Booster Guide, LEIN Clinic Rejuran Column. These are clinic-specific procedure and recovery guides and were not used as actual patient outcomes.
- Gangnam Unni, Babitalk. We quoted short excerpts from the original text describing pain, recovery, and perceived changes. We distinguished the review's writing/revision date from the actual treatment date.
Editorial responsibility and interests
Writing and editing were handled by the Korea Beauty Report editorial team. There is no direct medical review, and we have no contract, advertising, or financial relationship with the clinics introduced.
Reviews were quoted verbatim from the original text without nicknames or photos. We referenced the existing pain classification for the first 120 reviews on Gangnam Unni and search data for 307 reviews labeled as Rejuran on Babitalk, but we re-checked the original text of 8 publicly quoted reviews. We did not read the entire search results, nor did we interpret this material as representative of all users. We distinguished between clinic guidance and personal experience, and between manufacturer instructions and research findings.
First published: 2026-10-24. Last data check: 2026-10-24.